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PHCBI Incusafe Multi Gas Incubator / 50 liters

PHCBI Incusafe Multi Gas Incubator / 50 liters

PHCBI Incusafe Multi Gas Incubator / 50 liters

The MCO-50M series is combined with the MCO-170AIC/230AIC series in terms of design and features. It achieves high quality despite its small size. The DUAL IR Sensor allows for highly accurate CO2 averages and is also unaffected by humidity. The elimination of condensation with the humidity control rod can further prevent decontamination. The H2O2 decontamination system (OP), which does not require the removal of internal parts, can be decontaminated for approximately 2.5 hours. Reproduction of in vivo conditions With its unique, solid-state zirconium sensor for precise oxygen control (1-18%; 22-80%), the MCO-50M Multigas Incubator can reproduce the low oxygen concentrations found in many tissues and organs.

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PHCBI Incusafe Multi Gas Incubator / 165 liters

PHCBI Incusafe Multi Gas Incubator / 165 liters

PHCBI Incusafe Multi Gas Incubator / 165 liters

The IncuSafe MCO-170M Multi-Gas Incubator offers the most precise regulation of oxygen and other gases while maintaining superior temperature uniformity, contamination control and usability. The dual Infrared sensor provides ultra-fast CO2 recovery without overshooting, even after multiple door openings, while the unique solid Zirconium O2 sensor provides precise control of physiological oxygen levels to simulate in vivo conditions. Precise Cell Culture Culturing cells at physiological oxygen levels allows them to grow faster, live longer and mutate less. The IncuSafe MCO-170M Multi-Gas Incubator helps achieve more accurate results when culturing cells at physiological oxygen levels, making it ideal for mammalian tissue research applications, cellular therapy, stem cell research, pathophysiological studies and pharmaceutical manufacturing processes.

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Frequently Asked Questions

The only way to reduce the oxygen concentration inside the incubator below atmospheric levels (21% O₂) is to dilute the oxygen by introducing another inert (non-reactive) gas into the chamber. Tri-gas incubators use nitrogen (N₂) gas to lower and maintain the oxygen concentration at a target low level (such as 1% or 5% O₂), based on feedback from highly sensitive O₂ sensors. Therefore, in addition to a CO₂ cylinder, these systems also require a connection to an N₂ cylinder or nitrogen generator.

No, in most cases it cannot. Tri-gas incubators are manufactured with specialized O₂ sensors, additional gas inlet valves, nitrogen control microprocessors, and a different internal air circulation design. Standard CO₂ incubators are only equipped with the infrastructure required to control CO₂ levels within a range of 0–20%.

Description

What Is a Tri-Gas Incubator? Functions and Applications

In many advanced cell culture studies conducted in laboratory environments, temperature and CO₂ control alone are not sufficient to replicate in vivo physiological conditions. While atmospheric oxygen levels are approximately 21%, oxygen concentrations within human tissues range between 1% and 14%. Tri-Gas Incubators are advanced laboratory instruments that precisely control carbon dioxide (CO₂) and oxygen (O₂) levels in addition to temperature and humidity, allowing researchers to accurately simulate the hypoxic (low-oxygen) or physioxic (physiological oxygen) conditions found in natural biological environments.
These systems operate by injecting nitrogen (N₂) gas in a controlled manner to reduce and maintain the desired oxygen concentration within the chamber.

Core Functions and Scientific Importance of Tri-Gas Incubators

  • Hypoxia and Physioxia Simulation: Standard incubators expose cells to atmospheric oxygen levels (21% O₂). This can lead to hyperoxia (oxygen stress/toxicity) and the formation of reactive oxygen species (ROS) in many sensitive cell types. Tri-gas incubators maintain oxygen levels between 1% and 19%, enabling cells to exhibit behavior that more accurately reflects their natural physiological environment.
  • Precise O₂ and CO₂ Regulation: Thanks to advanced zirconia or paramagnetic oxygen sensors, gas parameters can rapidly return to their preset values after even brief door openings, ensuring minimal recovery time.
  • Impact on Cellular Metabolism: Precise control of oxygen gradients directly influences the accuracy of studies involving gene expression, signaling pathways, cell differentiation, and cellular energy metabolism, including glycolysis and oxidative phosphorylation transitions.

Applications and Industry Uses

Tri-gas incubators are considered the gold standard in critical research areas where cellular microenvironment control is essential:
  • In Vitro Fertilization (IVF): Oxygen concentration inside the uterus is naturally low (2–5%). The use of tri-gas incubators in IVF laboratories is essential for healthy embryo development, improved blastocyst quality, and increased pregnancy success rates.
  • Cancer Research (Oncology): The inner regions of solid tumors are highly hypoxic due to inadequate vascularization. Mechanisms such as tumor growth, angiogenesis (new blood vessel formation), chemotherapy resistance, and metastasis can only be accurately studied when this hypoxic microenvironment is reproduced.
  • Stem Cell Research: Stem cells reside in specialized low-oxygen environments known as stem cell niches. Specific oxygen levels are required to expand stem cells without losing pluripotency or to induce controlled differentiation into targeted cell types.
  • Tissue Engineering and Regenerative Medicine: These incubators are used to manage oxygen diffusion and gradients within three-dimensional (3D) scaffolds during the development of artificial tissues and organs.
  • Neurobiology and Cardiovascular Research: They are essential for modeling pathological conditions involving oxygen deprivation, such as stroke, ischemia-reperfusion injury, and myocardial infarction, at the cellular level.

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